How Scientists Are Trying to Develop a Coronavirus Vaccine | WSJ


(pleasant synth music) – Scientists at the National
Institutes of Health are working to create a
vaccine for the new coronavirus that originated in China, but they’re not starting from scratch. They’re employing an approach called Vaccine Rapid Response Platforms. It involves high-tech methods
that have the potential to shave years off of development time. Ideally, they’d offer protection while an epidemic is still
spreading instead of years later. Within weeks of the world
learning about the Wuhan outbreak, Chinese scientists uploaded
the novel coronavirus’ genetic sequence to a public database. That allowed teams around the world to start designing a vaccine. Traditional methods require
an actual sample of the virus. Typically, scientists inactivate a virus using special chemicals before
it’s put into a vaccine. When the inactivated or weakened virus is injected into the body, the
immune system recognizes it as a foreign invader or an antigen. Vaccines use antigens to prime the body to protect against a particular virus, but vaccines developed with Rapid Response
Platforms work differently. Rather than directly injecting
antigens into the body, these types of vaccines
typically send instructions to cells in the body. It gets the cells to
produce antigen proteins that are specific to the
virus it’s designed to defeat. These instructions are in
the form of RNA or DNA, the molecules that contain the
code for building proteins. Scientists say this process
cuts down on development time because they don’t have
to grow the whole virus. Plus, once scientists identify
and create the instructions for one virus, they can
tweak those instructions to make a vaccine for a similar virus. – So think of the backbone
as a cassette player and the new virus sequence of our target, like from the new coronavirus, that sequence that we design, and think of it as a new cassette tape, so we can just slot it in. – You can slot in new virus antigens. – [Jason] Melanie Saville is the Director of Vaccine Research and Development at the Coalition for
Epidemic Preparedness. CEPI is a global partnership that was launched at Davos in 2017. – We were actually formed specifically to look at this type of situation. – [Jason] In this situation, the emergence of a new coronavirus, CEPI’s funding several
teams from around the world that Saville says are
each independently working from the platform model. – The sort of technologies
that we are looking at, some of which are really quite pioneering, can really move very quickly. (pleasant orchestral music) – [Jason] Three of the candidates are in a category called
nucleic acid vaccines. One of those candidates is Moderna, which is working with the NIH. They’re developing a vaccine on a platform that uses a part of
the virus’ genetic code called messenger RNA or mRNA, so again, unlike the
conventional approach, with mRNA vaccine platforms, it’s our own body’s cells
rather than lab techs that produce the antigen proteins that are like the ones
made by the coronavirus. – Your immune system
then will be stimulated and develop antibodies to the virus so that when you see it again, it can immediately recognize the virus and prevent you from becoming sick. – [Jason] More and more
people are becoming sick from the novel coronavirus. As the race for a viable
vaccine continues, public health officials don’t know how bad the situation will be
by the time they hope to have a vaccine ready for
widespread distribution. – Normally, vaccines would take years to get into the clinic, so
the sort of technologies that we are looking at can
really move very quickly. So an example of that is
getting from identifying the sequence of the virus
to developing a vaccine, doing all of the pre-clinical testing, manufacturing, and getting
into the clinic in 16 weeks. – [Jason] So, around four months. During the 2003 SARS outbreak,
that process took 20 months. Experts say if one of the
four teams CEPI is funding is successful, it would a
watershed moment for human health. – These are very promising candidates, but they’re still quite early days.

100 Comments

  1. D C said:

    A virus is literally code… we are living in a simulation.

    February 17, 2020
    Reply
  2. Alek Jan said:

    0:07 thanks to china, they wanted more recognition on the international level, now they have it, more people will despise them now, good job

    February 17, 2020
    Reply
  3. Hardened Steel said:

    They should make this video after they have developed effective medicine.

    February 17, 2020
    Reply
  4. sean lim said:

    So much talk, but where is the vaccine? Is it released into the market yet?

    February 17, 2020
    Reply
  5. kntwing.23 said:

    good luck scientists hard work will pay off..

    February 17, 2020
    Reply
  6. Panda Pica said:

    Powerful Immune System Support
     https://healthysupplement.net/product/turmeric-with-bioperine/

    February 17, 2020
    Reply
  7. JM _324 said:

    Plague inc players, take notes!

    February 17, 2020
    Reply
  8. Mar Ke said:

    Check with Israel – they created this bio-weapon, they have the vaccine.

    February 17, 2020
    Reply
  9. Jobs mine said:

    As always it’s always the West that comes up with a solution.. even if it’s the Asians who mess with animals in the first place. 🤦‍♂️

    February 17, 2020
    Reply
  10. 🔴Warped🔴 said:

    If the virus killed rich people, they'd have a cure already.🤔

    February 17, 2020
    Reply
  11. jet black said:

    Stop it while it is still spreading? Is that why CDC reported a jump to 14,000 from 12000 in just a month? A 2000 new death within a month.
    https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=42&cad=rja&uact=8&ved=2ahUKEwjs1NmI_dfnAhUyIDQIHeZTCuQQFjApegQIAxAB&url=https%3A%2F%2Fabcnews.go.com%2FHealth%2F1300-people-died-flu-year%2Fstory%3Fid%3D67754182&usg=AOvVaw2B28Nq03kv98YF5bx-KI4F

    February 17, 2020
    Reply
  12. wazza33racer said:

    We know that corona is weaponized with components from HIV……………..if you cant get a vaccine working for HIV, then you wont get a vaccine for Corona, unless its makers gave it a weakness. Corona hammers down the white blood cell numbers so the immune system is screwed, its why its makers inserted genes from HIV, to give it better latency inside the body to spread more widely before symptoms manifest. The only way a virus can do that is to manipulate the immune system into ignoring it, like HIV does. DUH.

    February 17, 2020
    Reply
  13. Daicy & Mia Luv said:

    Many infected people's, and increasing mortality rate everyday..prayers for all..

    February 17, 2020
    Reply
  14. Xiaomi China said:

    The Corona virus 😷 said "MADE IN CHINA "

    February 17, 2020
    Reply
  15. Pahadi Driver said:

    come to India, it's 50'C no virus can survive that 🙂

    February 17, 2020
    Reply
  16. Proud said:

    https://www.youtube.com/watch?v=ZC0gww2yznI

    February 17, 2020
    Reply
  17. Minority Voice said:

    Artificial intelligence will wipe this sector out man future going be insane

    February 17, 2020
    Reply
  18. GhostRun Gacha 666 said:

    Dislikes are from Chinese government

    February 17, 2020
    Reply
  19. Jason Bourne said:

    AntiVaccer will not believe vaccine. They believe in natural healing 🙏

    February 17, 2020
    Reply
  20. Muhammad Shabbir said:

    The Carona Virus 100% could be defeating and controls by the using of subject composition as a syrup considering one doze tablespoon taken every 4 hours only three time then hopefully that the patient will be soon going towards recovering stage positively. The main components of the product base on 4 types of our daily use life grediants each one taken equally like 125g respectively (Onion, Garlic, Lemon, Ginger) mixup and grind then cooking 15 minutes with little quantity of Oil at low heat when its comes up brown color then add in half litter of Water at least boiling 30 minutes after the cool down of subject mixture on its room temprature then taken lequid type syrup as mention in above doze, Which could be defenatly and strongly react against the Crona Virus in the Human beings our Planet of Earth which will be finish as soon due to the utilization of subject medication.???

    February 17, 2020
    Reply
  21. Jimbert Codera said:

    FACT : I didn't understand what are they talking, but MILLION THANKS for THEM !!!

    February 17, 2020
    Reply
  22. stevenn gates said:

    They better be fast

    February 17, 2020
    Reply
  23. flame phoenix said:

    now that what i wanna hear find some to help people get better and kill that mess coronavirus is they sure where that nasty virus come from

    February 17, 2020
    Reply
  24. imeldo marcos said:

    No vaccine because it's not widespread yet, no profit.

    February 17, 2020
    Reply
  25. Sachin Georgé said:

    the persons who made the corona virus will be the ones releasing the vaccine

    February 17, 2020
    Reply
  26. Blue Sky said:

    It can take up to 10 years to develop a vaccine.

    February 17, 2020
    Reply
  27. Deni Kunci said:

    corona vaccine
    https://youtu.be/caTTOpMFz5g

    February 17, 2020
    Reply
  28. anom 7213 said:

    This vaccine will kill people.

    February 17, 2020
    Reply
  29. Eleeth Tahgra said:

    Just as long as it doesnt form i am legend scenario, I am game.

    February 17, 2020
    Reply
  30. Aje Shaluba said:

    SHARE THE TRUTH CORONA VIRUS IS SPREADING
    https://youtu.be/b1WzOqw3cHs

    February 17, 2020
    Reply
  31. Al Sun said:

    Since SARS died out during summer, will this COVID-19 di the same? Anyone studied if this virus can be killed by heat and radiation?

    February 17, 2020
    Reply
  32. D'Merchant Prince said:

    They already have way before the virus breakout… they are just waiting to hit a target of DEMAND 📈

    February 17, 2020
    Reply
  33. New albums songs said:

    I have medicine for corona

    February 17, 2020
    Reply
  34. SKY Hail Education said:

    Why why Plague Corona19 Sars Why all deadly diseases cam out from China Why???
    it's my question why really why?

    February 17, 2020
    Reply
  35. Chimera 888 said:

    The bad news is that within a little under half a month it will become world news.

    February 17, 2020
    Reply
  36. Cosmo John said:

    Covid-19 will disappear suddenly around April to June period this year. So, just like SARS there will be no vacine required nor produced. It takes years to clear all the tests. So it's not practical. There will be new Novel viruses in future. So, that's how it works

    February 17, 2020
    Reply
  37. Apple Arlene Joy Galanto said:

    been thinking about these brainy people are into very futuristic anti-vacc, WHAT IF what they need to do is go back to the basics, and do natural first aides. like if what patients need is ventilation, they should have a very well ventilated ward. and flu usually dies if the weather is hot, so they should turn off their aircon and let their patients go to the rooftop to have a sunbath every now and then. I'm just thinking, maybe our body is too immuned to advanced meds, maybe it's time to go back to basics.

    February 17, 2020
    Reply
  38. sam samte said:

    They don't even create the exact vaccine for SARS… How the fok yall people still hoping and believing to get this vaccine?? Its useless stop making this type of videos just comeback and make a video once you got the right vaccine…

    February 17, 2020
    Reply
  39. superblonde said:

    Plot Twist: Trump created the virus so the world will back his ridiculous Space Force in a mission to send MAGA Midwesterners to Mars

    February 17, 2020
    Reply
  40. Limely - said:

    Sounds a little like Parasite Eve?Sending signals to body cells to “self aware”?

    February 17, 2020
    Reply
  41. Y T said:

    Really wish WSJ would find a different guy to do these videos. His voice and attitude are so arrogant and annoying.

    February 17, 2020
    Reply
  42. Melanie Broome said:

    Anyone else see this as a COMPLETE irreversible experiment!! Seriously. It causes each cell to put out RNA/DNA for the virus "code" that the scientists plug into the vaccine. We have NO idea how that affects our body and all of our cells over the long run. Now add 5, 10, or 15+ different "codes" we are injected with over time.. how do these interact? What other effects are we having on each of the cells in our body? Its just one HUGE laboratory experiment. No wonder we have an unprecedented number of auto-immune diseases. The body is being experimented on. By their own words.. I trust my body to do what it is brilliantly designed to do over choosing to take injections that permanently alter what each cell is doing, without anyone knowing the long term effect!

    February 17, 2020
    Reply
  43. National Dossier said:

    So… the vaccine is an injection of DNA and RNA? So you are injecting a virus then, no? I.E. Hepatitis C – Viral infection. if you had it or have it, you test positive for Hep C on DNA tests. To verify that you have it, they do a RNA test. If you're positive for RNA you have it because RNA is activated virus.
    Why would I want anyone injecting an active version of anything into me, regardless of anything? And did the same thing not happen with H1N1, which many accused pharma companies of falsifying news and propagandizing an illness into something it wasn't. Same with Ebola, the hype around that was insane and yet, nothing happened here.

    It's the same process EACH TIME, we go through this every 5-10 years, are we gonna keep falling for this?
    May I add, we are approaching the end of the "2020 Adult Immunization Plan" in which a plan is outlined to get all people in the United States vaccinated by the end of 2020. Good timing I guess

    February 17, 2020
    Reply
  44. Wesley Ashley said:

    When developed in a hurry long term side effects cannot be known until they happen to the people vaccinated. These could be worse than the disease.

    February 17, 2020
    Reply
  45. lylymom said:

    will the vaccine provide free to the world or charge with some money? i hope it free 🙂

    February 17, 2020
    Reply
  46. WOWCruiser said:

    DO THIS FOR HIV FIRST!!! 😒

    February 17, 2020
    Reply
  47. Anindya Roy Chowdhury said:

    Why not find a cure or a vaccine for aids….if it's so fast and effective tech

    February 17, 2020
    Reply
  48. mihai nica said:

    🤔 so if some president or important people will get infected that work on vaccine im sure will be more faster, no sh… the cure is in dirty hands and the people cant accept that virus in the global goverments, the goverment is not the solution is the problem in this world

    February 17, 2020
    Reply
  49. Doug Doug said:

    Any vaccines that they create in under a few years time, is a vaccine you don’t not want in your system.

    It’s either going to cause massive internal damage, or if it works, it proves that this virus man made.

    February 17, 2020
    Reply
  50. anthony chinwo said:

    Bioshock Plasmids, congrats on inventing!

    February 17, 2020
    Reply
  51. Epyonwings said:

    I hope they find a cure. 🤒

    February 17, 2020
    Reply
  52. M Wilson said:

    A vaccine should have already been developed

    February 17, 2020
    Reply
  53. Ronaldo apelyido said:

    Don't eat bats…

    February 17, 2020
    Reply
  54. Angela Gomez said:

    Go ask China, they created it in a bio-lab and they have a vaccine already. Don't think this was not planned.

    February 17, 2020
    Reply
  55. Ballz said:

    Summary: you can just slide it in.

    February 17, 2020
    Reply
  56. sna2600 said:

    If you can rewrite the genetic code for a virus then you can create a ethinical bioweapon

    February 17, 2020
    Reply
  57. alexperez85 said:

    First they say its very quick.. next they say its not quick.. so which is the correct answer?

    February 18, 2020
    Reply
  58. Jam Ram said:

    Release the virus on enemy territory then sell them the cure. America knows how to win wars. Who won the economic trade war now? America knows how to make money.

    February 18, 2020
    Reply
  59. HUNG MIN said:

    The Corona will be just like HIV, we just live with them. Virus vaccines? It's over 30 yrs already where is the HIV vaccine? Maybe it's on the top of Mount Sinai. Mount Sinai (Hebrew: הַר סִינַי‬, Har Sinai) is the mountain at which the Ten Commandments were given to Moses by God, and is one of the most significant of the Stations of the Exodus.

    February 18, 2020
    Reply
  60. Dominick Dougherty said:

    Wow

    February 18, 2020
    Reply
  61. Dominick Dougherty said:

    The government created this.

    February 18, 2020
    Reply
  62. abdirhman ali said:

    Depopulation method not falling for it.

    February 18, 2020
    Reply
  63. TR Labs said:

    I'll same you the time, drink 16oz distill water and mix with 1 teaspoon of baking soda two times a day. Baking soda kill all viruses!

    February 18, 2020
    Reply
  64. Echad Lev Shtim said:

    They create these virus. They use tv propaganda to hype up fear, then once they begin injecting it in cowards who wish to escape natural selection, an outbreak occurs. Rinse and Repeat.
    Follow it up with anti vaxxer ad hominem rhetoric and you got a fool proof scam that produces its own statistics simply by creating the problem that later arises. As if humans that existed for around 2 million years somehow need a medical safety net from extinction. Heres some statistics:
    7 billion humans – 10,000 deaths= 6 billion forced intravenous concoctions designed by a medical industry that kill over 200,000 annually with anti lawsuit articles in place to prevent accountability of damages. Its more likely that doctors will kill you before some silly hoax before the scam plays out from greedy corporate america that hold more Constitutional rights than the flesh and blood that wrote it.

    February 18, 2020
    Reply
  65. 1ndiankapkan said:

    Karen's won't vaccinate

    February 18, 2020
    Reply
  66. VOIP Portland said:

    Vaccine = fail. Just a money grab for them, Thermasol for you.

    February 18, 2020
    Reply
  67. Jophy Joe said:

    https://youtu.be/RMvQa2WgLFo

    February 18, 2020
    Reply
  68. HoneyChai said:

    This will never be called Covid-19 by anyone. It's forever Wuhan Virus. I mean who doesn't want to say Woohan virus? It's fun to say. It just rolls off the tongue. It's sounds like a virus when you say Wuhan Virus. If I say I have Wuhan people will sympathize with me. If I say I have Covid-19 people will ignore me and continue eating their crackers and caviar. Wuhan is a conversation starter.

    February 18, 2020
    Reply
  69. OnA Mission said:

    VACCNES? AFTER GETTING CAUGHT RED HANDED PUTTING KNOWN POISONS AND CARCINOGENS THEN CREATING NO FAULT VAX COURTS? PROPAGANDA

    February 18, 2020
    Reply
  70. Manda 3D Projects said:

    2:08 Bill Gates is on the middle

    February 18, 2020
    Reply
  71. Subaru Natsuki said:

    Nah, alot of people survived it.

    February 18, 2020
    Reply
  72. mason congo said:

    The Western governments and Chinese government invented Coronavirus to discrease Chinese population. Next virus is going to be in India and Philippine because of high population they contain…

    February 18, 2020
    Reply
  73. John Papadopoulos said:

    I still do not understand how is this message given to the cell. Do they use recombinant DNA to change the sequence of the human cell? If they in fact do that I think it would better to grow the virus instead. I gave rapid response platform a google search and it came back with nothing… First time I hear that so I wanted to see what it actually is?

    February 18, 2020
    Reply
  74. SMASHING said:

    It wouldn’t surprise me if they invented the virus, spread fear into the world and make a ton of money selling the vaccin.

    February 18, 2020
    Reply
  75. cindy flores said:

    METH WILL KILL IT! JUST SAYING…

    February 18, 2020
    Reply
  76. the killer1019 said:

    Whole time they using the virus as an excuse to change our dna sequence

    February 18, 2020
    Reply
  77. cindy flores said:

    Don't believe me? try it
    iT SOUNDS CRAZY I KNOW BUT…..

    February 18, 2020
    Reply
  78. winter rose said:

    They have to run the numbers to see how to profit the most from human misery. Big farm is still big farm remember. By the way China has its own version of Big farm

    February 18, 2020
    Reply
  79. Dare Bias said:

    I stated this before they even started this process for the vaccine smh I swear they delay of doing things but at least finally they doing something but it may need another vaccine to keep it in tact . Mark my words am stating this. Before they do.

    February 18, 2020
    Reply
  80. OSUS said:

    What if they found the vaccine,but the virus mutated.

    February 18, 2020
    Reply
  81. fleamarketmutt said:

    Stop your lies we found the US patents on all strains of coronavirus.

    February 18, 2020
    Reply
  82. CeedayTweeday said:

    So herion is healthy Nice

    February 18, 2020
    Reply
  83. Alex T said:

    Why all this work when they could easily get the vaccine from the Wuhan Bioweapon lab the virus escaped from?

    February 18, 2020
    Reply
  84. Beancake Data said:

    Hope a cure is found soon and everyone gets better soon!

    February 18, 2020
    Reply
  85. The Cave All Strayed Up said:

    In short, scientists are injecting DNA and RNA information into the infected's body's cells versus going through the middle man by having the virus itself help produce antigens (which go into the vaccine) in the lab. Then, the infected's own cells produce the antigens. Now if they could just transfer this philosophy to social programs where Auschlitzians are required to get their help from the fascist leaders of their families, neighborhoods, workplaces, schools and so on. It's not rocket science. Oppression is just as easy to deal with. They just won't let us.

    February 18, 2020
    Reply
  86. Crazysammy Jammy said:

    Vaccine:i cant do it
    Summer:fine
    Virus:is everyone melting?

    February 18, 2020
    Reply
  87. SY S said:

    or just use paracetamol

    February 18, 2020
    Reply
  88. Muhammad Muneeb said:

    This could have been way worse if it were any other country.

    February 18, 2020
    Reply
  89. Ellis Meyer said:

    In other words, from this point forward, every time there is an outbreak they will want to vaccinate everyone

    February 18, 2020
    Reply
  90. Andrew Behrens said:

    All this technology and we still aren’t fast enough

    February 18, 2020
    Reply
  91. Krs Villegas said:

    https://youtu.be/dy1xZiUpwEs
    They turn to zombies

    February 18, 2020
    Reply
  92. Doc Hu said:

    When will covid vaccine made??

    February 18, 2020
    Reply
  93. Dipankar Mishra said:

    What the result Dr .
    Do we have any medicine for this
    Virus.
    Dear Dr , please be god for us .
    Peoples are waiting for you .
    Please save china n entire world .
    Lots of respect From India 🙏🌹🇮🇳

    February 18, 2020
    Reply
  94. Gregory Glavinovich said:

    corona virus created in a Lab probably Fort Detrick Maryland where AIDS virus was created = link = https://www.youtube.com/watch?time_continue=61&v=DA4a_wXDOeA&feature=emb_logo

    February 18, 2020
    Reply
  95. devil hacker said:

    阿拉帮助我的中国兄弟姊妹巴基斯坦与我同胞我的中国人

    February 18, 2020
    Reply
  96. Ariana ali said:

    I knew they were gonna come out with a bs vaccine. 🙄

    February 18, 2020
    Reply
  97. RafinGameBoys said:

    thats basiclie what nano robots does XDDDDDDD

    February 18, 2020
    Reply
  98. Daily Wonder said:

    Stop trying to fool the world. Vaccine has long been created and hide it in the lab.We are not stupid as you think.Corona virus is a bio-weapon.

    February 18, 2020
    Reply
  99. VoolRoblox_God said:

    Well the thing is….. San Diego already created a vaccine, but they said it would take 17 weeks for the vaccine to go on sale

    February 18, 2020
    Reply
  100. Mark Logan said:

    AMERICA IS THE ONLY COUNTRY THAT CAN COME UP WITH A VACCINE. The Chinese do not know how to handle this!!!

    February 18, 2020
    Reply

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